Set ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSet ELISA Kit for Rat(Rattus norvegicus)

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Set (Gene name),

Protein SET (Protein name ), SET_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Set(Ab1-115);

Protein name:

Protein SET;

Alternative:

Phosphatase 2A inhibitor I2PP2A(I-2PP2A);Liver regeneration-related protein LRRGR00002;Template-activating factor I(TAF-I);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Isoform 1 and isoform 2 interact also with histones. Isoform 2 is a component of the SET complex, which also contains ANP32A, APEX1, HMGB2 and NME1, but not NME2. Within this complex, directly interacts with NME1 and with HMGB2. Interacts with SETBP1 (By similarity). Interacts with SGOL1.

Function:

Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.

Subcellular Location:

Cytoplasm cytosol Endoplasmic reticulum Nucleus nucleoplasm In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. Following CTL attack, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium. The SET complex is associated with the endoplasmic reticulum.

Protein Attributes:

Sequence length:

289

Sequence:

50:

100:

150:

200:

250:

289:

DEEEEGLEDI | DEEGDEDEGE | EDDDEDEGEE | GEEDEGEDD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00956

String:

Q63945

UniGene:

Rn.76937

SMR:

Q63945

KEGG:

rno:307947

Uniprot:

Q63945

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ELISA Kit for Rat Protein SET

Cat.:

E14249h

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Packing:

96T

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ELISA Kit for Rat Protein SET

Cat.:

E14249m

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96T

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ELISA Kit for Rat Protein SET

Cat.:

E14249r

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Packing:

96T

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CLIA Kit for Rat Protein SET

Cat.:

U14249h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Protein SET

Cat.:

U14249r

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MSDS:

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Packing:

96T

CLIA Kit for Rat Protein SET

Cat.:

U14249m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Protein SET

Cat.:

P14249Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Protein SET

Cat.:

P14249Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Protein SET

Cat.:

P14249Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Protein SET

Protein for Rat Protein SET

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Spatially restricted expression of set mRNA in developing rat kidney."
Kim E.-G. , Choi M.E. , Ballermann B.J.
Am. J. Physiol.266:F155-F161(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Kidney.
2.

"Liver regeneration after PH."
Xu C.S. , Li W.Q. , Li Y.C. , Ma H. , Wang L. , Wang S.F. , Han H.P. , Wang G.P. , Chai L.Q. , Yuan J.Y. , Yang K.J. , Yan H.M. , Chang C.F. , Zhao L.F. , Shi J.B. , Rahman S. , Wang Q.N. , Zhang J.B.
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Liver.
3.

"Up-regulation of I-2PP2A/SET gene expression in rat primary hepatomas and regenerating livers."
Fukukawa C. , Shima H. , Tamura N. , Ogawa K. , Kikuchi K.
Cancer Lett.161:89-95(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY

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